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KMID : 0369820110410020083
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Jorunal of Korean Pharmaceutical Sciences
2011 Volume.41 No. 2 p.83 ~ p.90
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Evaluation of Physical Properties as Magnesium Stearate Blendedin Hydrophilic Matrix Tablets
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Choi Du-Hyung
Jung Youn-Jung
Wang Hun-Sik
Yoon Jeong-Hyun
Jeong Seong-Hoon
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Abstract
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Main objectives of this study were to investigate the effects of a lubricant, magnesium stearate, as blended in a hydrophilic matrix tablet and to identify significant factors using a tablet ejection force and a swelling property. The characteristics of tablet ejection were evaluated with three different compression forces (30, 40, and 60 MPa) and two controlled factors, amount of magnesium stearate and its mixing time. A hydrophilic model drug (terazosin HCl dihydrate) was regarded as a default factor. Tablet swelling was also evaluated. The optimal amount of PEG compared to PEO was set to be 88.50% w/w. As the amount of magnesium stearate was varied from 0.79% to 2.20% w/w, the amount of PEO and PEG was adjusted to meet the tablet's total weight while maintaining the ratio between the two excipients constant. As the mixing time of magnesium stearate was increased, the tablet ejection force and the swelling property were decreased. As the amount of magnesium stearate was increased, the tablet ejection force and the swelling property were decreased since the increased mixing time and the amount of magnesium stearate induced hydrophobic properties of the matrix tablet more effectively. The ejection force of the tablet increased as a result of increase in the compression force, which means that the breaking of tablet/die-wall adhesion energy was also increased when the compression energy was increased. The results gavea valuable guide how to choose suitable amount of the lubricant with processing conditions for the development of hydrophilic matrix formulations.
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KEYWORD
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Lubricant, Ejection force, Matrix tablet, Swelling kinetics, Hydrophilic swellable polymer
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